Silver Sulfadiazine Burn Ointment

Although major burns create a serious medical crisis, most of the burn patients die of infections rather than burns. Fox, a bacteriologist in a surgical unit, combined two known antibacterial agents for burns, silver nitrate and sulfadiazine, to create a synergistic compound that is extremely effective against infection. Silver sulfadiazine burn ointment was licensed to Marion Laboratories in 1969 following a clinical trial to prove efficacy.

Silver sulfadiazine quickly became the drug of choice due to its effectiveness at controlling bacterial infection and pain-free application. Produced as a water-soluble ointment, silver sulfadiazine was first employed on a large scale during the Vietnam War.

The U.S. patent for silver sulfadiazine issued in September 1973.

Inventor

Dr. Charles L. Fox Jr. (deceased) at Columbia University College of Physicians and Surgeons